Z3R0, the HIVEbot might be the best to kill. Though he is a robot, so he'll get rebuilt. Can't think of any characters who people would want dead though (I could be wrong)
Dart and I were going to do a thread at some point with a cargo ship (to Jump) was going to be hijacked by HIVE, and it's goods taken. Could do that with the entire HIVE, Isen and his group save...
Just one idea